Human megakaryocytes. III. Characterization in myeloproliferative disorders
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چکیده
منابع مشابه
Human megakaryocytes. III. Characterization in myeloproliferative disorders.
Abnormal proliferation of the megakaryocytic line was observed in the marrow tissue from patients with myeloproliferative disorders. Megakaryocytes were identified by immunofluorescence using distinct platelet protein markers. Plasma factor VIII antigen (factor VIII:AGN) and platelet glycoproteins IIb and IIIa were detected in normal mature and early megakaryocytes, as well as in a morphologica...
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Platelets are blood elements that play a key role in coagulation and participate directly in the processes of thrombosis and atherosclerosis (1-3). However, the physiologic mechanisms governing platelet formation and release from megakaryocytes remain largely unknown (4). Platelets are nonnucleated cells with only a vestigial protein synthetic apparatus, and therefore most of the structural and...
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Myeloproliferative disorders (MPDs) constitute a group of hematopoietic malignancies that feature enhanced proliferation and survival of one or more myeloid lineage cells. William Dameshek is credited for introducing the term "MPDs" in 1951 when he used it to group chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) under one cl...
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Small circulating megakaryocytes were nuclear. The circulating megakaryocytes identified in four patients with chronic were associated with the presence of myeloproliferative disorders, and their dysplastic platelets. Both findings are morphologic features by light and electron thought to represent involvement of the microscopy are described. The morphomegakaryocytic-platelet line, probably as ...
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ژورنال
عنوان ژورنال: Blood
سال: 1984
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v63.3.615.615